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Merck
CN

SAB4502857

Anti-SRPK1 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

SFRS protein kinase 1, SR-protein-specific kinase 1, Serine/arginine-rich protein-specific kinase 1

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

Key Documents

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biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 92 kDa

species reactivity

rat, mouse, human

concentration

~1 mg/mL

technique(s)

ELISA: 1:40000
western blot: 1:500-1:1000

NCBI accession no.

Q96SB4

UniProt accession no.

Q96SB4

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... SRPK1(6732)

Related Categories

General description

Anti-SRPK1 Antibody detects endogenous levels of total SRPK1 protein.
Serine-arginine protein kinase 1 (SRPK1) belongs to the SR kinase family. In mammals, SRPK1 is expressed in the central nervous system in a region- and neuron-specific manner. This gene is mapped to human chromosome 6p21.2-p21.3. SRPK1 is also expressed in several normal tissues like testis and pancreas.

Immunogen

The antiserum was produced against synthesized peptide derived from human SRPK1.

Immunogen Range: 521-570

Biochem/physiol Actions

Serine-arginine protein kinase 1 (SRPK1) modulates angiogenesis. Suppressing SRPK1 prevents the development and migration in renal carcinoma cells. In normoxic condition, SRPK1 can increase the migration and invasion of glioma cells.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

常规特殊物品
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Certificates of Analysis (COA)

Lot/Batch Number
3118616

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Knockdown of Serine?Arginine Protein Kinase 1 Inhibits the Growth and Migration in Renal Cell Carcinoma Cells.
Han X, et al.
Oncology Research, 25(3), 389-395 (2017)
Expression of SRPK1 in gliomas and its role in glioma cell lines viability.
Sigala I, et al.
Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine, 37(7), 8699-8707 (2016)
SRPK1 dissimilarly impacts on the growth, metastasis, chemosensitivity and angiogenesis of glioma in normoxic and hypoxic conditions.
Wu Q, et al.
Journal of Cancer, 4(9), 727?735-727?735 (2013)

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