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Merck
CN

SAB4502887

Anti-AURA antibody produced in rabbit

affinity isolated antibody

Synonym(s):

AIK, ARK1, Aurora-A, Aurora-family kinase 1, Aurora-related kinase 1

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About This Item

NACRES:
NA.43
UNSPSC Code:
12352203

Key Documents

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Product Name

Anti-AURA antibody produced in rabbit, affinity isolated antibody

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 45 kDa

species reactivity

mouse, rat, human

concentration

~1 mg/mL

technique(s)

ELISA: 1:5000
western blot: 1:500-1:1000

NCBI accession no.

O14965

UniProt accession no.

O14965

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... AURKA(6790)

Biochem/physiol Actions

AURA/AURKA (aurora kinase A) modulates cell cycle checkpoints and plays important roles in centrosome division, cytoskeleton and cytokinesis. It sustains the integrity of chromosome after DNA damage. The catalytic domain of AURKA possesses a serine/threonine kinase activity role. It is overexpressed in several malignancies like invasive carcinomas of ovary, head, neck and breast.

Features and Benefits

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General description

AURA/AURKA (aurora kinase A) is mapped on to human chromosome 20q13.2. It is also termed as STK15 (serine/threonine kinase 15). This gene codes for a protein of 403 amino acids with regulatory and catalytic domains.

Immunogen

The antiserum was produced against synthesized peptide derived from human AurA.

Immunogen Range: 311-360

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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Storage Class

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

常规特殊物品
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Certificates of Analysis (COA)

Lot/Batch Number
211132

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A single nucleotide polymorphism in codon F31I and V57I of the AURKA gene in invasive ductal breast carcinoma in Middle East
Golmohammadi R, et al.
Medicine (2017)

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