SAB4502945
Anti-Telomerase antibody produced in rabbit
affinity isolated antibody
Synonym(s):
EST2, HEST2, TCS1, Telomerase catalytic subunit, Telomerase reverse transcriptase
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 126 kDa
species reactivity
human
concentration
~1 mg/mL
technique(s)
ELISA: 1:1000
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... TERT(7015)
General description
Anti-Telomerase Antibody detects endogenous levels of total Telomerase protein.
The TERT (telomerase reverse transcriptase) gene is mapped to human chromosome 5p15.33 and encodes for a ribonucleoprotein.
Immunogen
The antiserum was produced against synthesized peptide derived from human Telomerase.
Immunogen Range: 796-845
Immunogen Range: 796-845
Biochem/physiol Actions
TERT (telomerase reverse transcriptase) catalyzes the de novo synthesis of telomere and results in cellular immortalization to maintain chromosomal stability. Mutations in TERT causes different types of malignancies such as gliomas, gastric cancer, and anaplastic thyroid cancer. Therefore, TERT serves as an early prognostic biomarker.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
nwg
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Human telomerase reverse transcriptase (hTERT) promotes gastric cancer invasion through cooperating with c-Myc to upregulate heparanase expression.
Tang B
Oncotarget, 7(10), 11364-11379 (2016)
Brain regions associated with telomerase reverse transcriptase promoter mutations in primary glioblastomas.
Fan X
Journal of Neuro-Oncology, 28(3), 455-462 (2016)
Silencing of hTERT blocks growth and migration of anaplastic thyroid cancer cells.
Maggisano V
Molecular and Cellular Endocrinology, 448, 34-40 (2017)
Lung cancer susceptibility locus at 5p15.33.
McKay JD
Nature Genetics, 40(12), 1404-1406 (2008)
The role of TERT-CLPTM1L SNPs, hTERT expression and telomere length in the pathogenesis of oral squamous cell carcinoma.
Carkic J
Journal of Oral Science, 58(4), 449-458 (2016)
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