SAB4502973
Anti-TIMP3 antibody produced in rabbit
affinity isolated antibody
Synonym(s):
Metalloproteinase inhibitor 3, Protein MIG-5, TIMP-3, Tissue inhibitor of metalloproteinases 3
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About This Item
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, WB
Citations:
6
biological source
rabbit
Quality Segment
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 24 kDa
species reactivity
mouse, rat, human
concentration
~1 mg/mL
technique(s)
ELISA: 1:10000, western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... TIMP3(7078)
General description
Tissue inhibitor of metalloproteinases 3 (TIMP3) belongs to the matrix metalloproteinases inhibitor family. TIMP3 gene is mapped to human chromosome 22q12.3. TIMP3 possesses a C-terminal N-linked glycosylation site at asparagine residue. This protein comprises 12 conserved cysteine residues stabilized by six disulfide bonds in its secondary structure. TIMP-3 gene expression is higher in murine lung and kidney.
Immunogen
The antiserum was produced against synthesized peptide derived from human TIMP3.
Immunogen Range: 91-140
Immunogen Range: 91-140
Biochem/physiol Actions
Tissue inhibitor of metalloproteinases 3 (TIMP3) inhibits membrane-type matrix metalloproteinases (MT-MMPs) and the tumor necrosis factor α–converting enzyme (TACE). It displays a high affinity for the proteoglycans associated with extracellular matrix (ECM) and displays tight binding with sulfated glycosaminoglycans. Mutations in the TIMP-3 gene is implicated in Sorsby′s fundus dystrophy which is characterized by choroidal neovascularization, vision loss, and abnormal Bruch′s membrane thickening. Downregulation of TIMP3 gene due to allelic losses on 22q12 chromosomal location is correlated to meningiomas. TIMP3 participates in cardiac remodeling. Low levels of TIMP3 protein are observed in scenarios of ischemic and dilated cardiomyopathy. This protein elicits proapoptotic activity and is an inhibitor of angiogenesis and tumor growth.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
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