SAB4503183
Anti-TUSC3 antibody produced in rabbit
affinity isolated antibody
Synonym(s):
N33, Protein N33, TUSC3, Tumor suppressor candidate 3
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, IF, WB
Citations:
11
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 39 kDa
species reactivity
mouse, human, rat
concentration
~1 mg/mL
technique(s)
ELISA: 1:10000, immunofluorescence: 1:100-1:500, western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... TUSC3(7991)
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General description
Tumor suppressor candidate 3 (TUSC3) codes for a subunit of the endoplasmic reticulum-bound oligosaccharyltransferase complex. It is a 348 amino acid protein, that has 11 exons spanning ∼224 Kbp of the genomic DNA. TUSC3 has five potential transmembrane domains and is located on human chromosome 8p22.
Immunogen
The antiserum was produced against synthesized peptide derived from human TUSC3.
Immunogen Range: 131-180
Immunogen Range: 131-180
Application
Anti-TUSC3 antibody has been used in immunohistochemistry, immunoblotting and co-immunoprecipitation.
Biochem/physiol Actions
Tumor suppressor candidate 3 (TUSC3) is a tumor suppressor gene, that is responsible for autosomal recessive mental retardation. It participates in catalyzing the transfer of a 14-sugar oligosaccharide from dolichol to nascent protein. Absence of TUSC3 is associated with lymph node metastasis in larynx and pharynx squamous cell carcinomas.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
低风险生物材料
常规特殊物品
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Shoujie Wang et al.
Cell biochemistry and function, 38(5), 604-612 (2020-02-25)
Melanoma is a highly malignant and is a life-threatening disease with no effective treatment currently. This study aims to evaluate the significance of TUSC3, an endoplasmic reticulum stress (ERS)-inducible gene and explore its relationship with AKT/GSK3-β/β-catenin signalling pathway in melanoma
Ahmed Magzoub Khalid et al.
Bioscience, biotechnology, and biochemistry, 77(10), 2019-2024 (2013-10-08)
Analysis of microarray data obtained by comparing gene expression between 2-week-old infant and 7-week-old mature SD rat testes revealed novel targets involved in tumor suppression. Reverse-transcription polymerase chain reaction and Northern blotting indicated that Tusc3 gene expression was upregulated in
Oncogenic function of TUSC3 in non-small cell lung cancer is associated with Hedgehog signalling pathway
Gu Y, et al.
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1863(7), 1749-1760 (2017)
A defect in the TUSC3 gene is associated with autosomal recessive mental retardation
Garshasbi M, et al.
American Journal of Human Genetics, 82(5), 1158-1164 (2008)
Yansong Ren et al.
Carcinogenesis, 41(12), 1755-1766 (2020-04-28)
Tumor suppressor candidate 3 (TUSC3) is a coding gene responsible for N-glycosylation of many critical proteins. TUSC3 gene plays an oncogenic role in colorectal cancer (CRC), however, the role of TUSC3 in drug resistance of CRC is still unclear. The
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