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Merck
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SAB4503322

Anti-USP44 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Deubiquitinating enzyme 44, USP44, Ubiquitin carboxyl-terminal hydrolase 44, Ubiquitin thioesterase 44, Ubiquitin-specific-processing protease 44

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, WB
Citations:
3

Key Documents

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 81 kDa

species reactivity

human

concentration

~1 mg/mL

technique(s)

ELISA: 1:40000, western blot: 1:500-1:1000

NCBI accession no.

Q9H0E7

UniProt accession no.

Q9H0E7

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... USP44(84101)

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General description

Anti-USP44 Antibody detects endogenous levels of total USP44 protein.
USP44 (ubiquitin-specific protease 44) codes for a 712 amino acid protein. It belongs to the ubiquitin-specific protease (USP) family. USP44 contains a ZnF-UBP (zinc-finger ubiquitin-specific protease) domain and conserved cysteine, histidine and asparagine/aspartic acid residues.It is abundantly expressed in the nucleus. It is mapped to human chromosome 12q22.

Immunogen

The antiserum was produced against synthesized peptide derived from human USP44.

Immunogen Range: 211-260

Biochem/physiol Actions

USP44 (ubiquitin-specific protease 44) plays a major role in the mitotic checkpoint. Absence of USP44 leads to chromosome mis-segregation, aneuploidy and tumorigenesis in vivo.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

低风险生物材料
常规特殊物品
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Certificates of Analysis (COA)

Lot/Batch Number
3119388

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DNA Aneuploidy in Malignant Salivary Gland Neoplasms is Independent of USP44 Protein Expression.
Bernardes VF, et al.
Brazilian Dental Journal, 28(2), 148-151 (2017)
K48- and K63-linked polyubiquitination of deubiquitinating enzyme USP44.
Suresh B, et al.
Cell Biology International, 34(8), 799-808 (2010)
Ying Zhang et al.
The Journal of clinical investigation, 122(12), 4362-4374 (2012-11-29)
Most human tumors have abnormal numbers of chromosomes, a condition known as aneuploidy. The mitotic checkpoint is an important mechanism that prevents aneuploidy by restraining the activity of the anaphase-promoting complex (APC). The deubiquitinase USP44 was identified as a key

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