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SAB4503399

Anti-LAT3 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

L-type amino acid transporter 3, Prostate cancer overexpressed gene 1 protein, SLC43A1, Solute carrier family 43 member 1

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, WB
Citations:
3

Key Documents

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 61 kDa

species reactivity

human

concentration

~1 mg/mL

technique(s)

ELISA: 1:20000, western blot: 1:500-1:1000

NCBI accession no.

O75387

UniProt accession no.

O75387

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... SLC43A1(8501)

Related Categories

General description

Anti-LAT3 Antibody detects endogenous levels of total LAT3 protein.
LAT3/SLC43A1 (solute carrier family 43 member 1), a Na+-independent neutral L-amino acid transporter, is mapped to human chromosome 11q12.1. It is expressed in liver, skeletal muscle and pancreas.

Immunogen

The antiserum was produced against synthesized peptide derived from human LAT3.

Immunogen Range: 231-280

Biochem/physiol Actions

LAT3/SLC43A1 (solute carrier family 43 member 1) is essential for the growth and activities of podocytes. In prostate cancer cell lines, silencing the expression of LAT3 stops the initiation of mTORC1 (mammalian target of rapamycin complex 1) pathway activation, cell growth and cell cycle both in vitro and in vivo.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
3110170

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Monoterpene glycoside ESK246 from Pittosporum targets LAT3 amino acid transport and prostate cancer cell growth
Wang Q, et al.
ACS Chemical Biology, 9(6), 1369-1376 (2014)
Amino acid transporter LAT3 is required for podocyte development and function
Sekine Y, et al.
Journal of the American Society of Nephrology, 20(7), 1586-1596 (2009)
Genome-wide analysis of pancreatic cancer using microarray-based techniques.
Harada T
Pancreatology : Official Journal of the International Association of Pancreatology (Iap) ... [Et Al.], 9(1-2), 13-24 (2009)

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