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Merck
CN

SAB4503508

Anti-WAVE1 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

KIAA0269, SCAR1, Verprolin homology domain-containing protein 1, WAS1, WASF1

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About This Item

MDL number:
MFCD04118689
UNSPSC Code:
12352203
NACRES:
NA.41

Key Documents

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biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 61 kDa

species reactivity

mouse, human, rat

concentration

~1 mg/mL

technique(s)

ELISA: 1:40000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI accession no.

Q92558

UniProt accession no.

Q92558

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... WASF1(8936)

General description

Wiskott–aldrich syndrome protein family member 1 (WAVE1) is encoded by the gene mapped to human chromosome 6q21-22. It is primarily expressed in brain and is characterized with a tripartite VCA (verprolin homology, cofilin homology and acidic) domain.

Immunogen

The antiserum was produced against synthesized peptide derived from human WAVE1.

Immunogen Range: 91-140

Application

Anti-WAVE1 antibody produced in rabbit has been used in immunoblotting.

Biochem/physiol Actions

Members of WASP-family verprolin-homologous protein (WAVE) family plays a vital role in actin polymerisation and cytoskeletal organisation, which are essential for various cellular processes, including cell shape changes, cytokinesis, cell motility and membrane traffic. WAVE1 regulates chemoresistance during autophagy. The encoded protein plays an essential role in oligodendrocyte morphogenesis and myelination. In addition, it is also implicated in regulation of spine morphogenesis. Overexpression of the gene leads to the development of prostate cancer.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
210598

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WAVE1 is required for oligodendrocyte morphogenesis and normal CNS myelination.
Kim H J, et al.
The Journal of Neuroscience, 26(21), 5849-5859 (2006)
Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex.
Suetsugu S, et al.
Biochemical and Biophysical Research Communications, 260(1), 296-302 (1999)
Phosphorylation of WAVE1 regulates actin polymerization and dendritic spine morphology.
Kim Y, et al.
Nature, 442(7104), 814-814 (2006)
Expression of the WASP verprolin-homologues (WAVE members) in human breast cancer.
Fernando H S, et al.
Oncology, 73(5-6), 376-383 (2007)
Knockdown of WAVE1 enhances apoptosis of leukemia cells by downregulating autophagy.
Zhang Z, et al.
International Journal of Oncology, 48(6), 2647-2656 (2016)
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