SAB4503568
Anti-EXO1 antibody produced in rabbit
affinity isolated antibody
Synonym(s):
EXO1, Exonuclease 1, Exonuclease I, hExo1, hExoI
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, IF, WB
Citations:
5
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 94 kDa
species reactivity
human, mouse
concentration
~1 mg/mL
technique(s)
ELISA: 1:10000, immunofluorescence: 1:100-1:500, western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... EXO1(9156)
General description
Anti-EXO1 Antibody detects endogenous levels of total EXO1 protein.
Exonuclease 1 (EXO1), a member of RAD2 nuclease family, comprises an amino-terminal (N) domain, intermediate spacer region and an internal (I) domain with cysteine and glutamate residues. The Exo 1 gene is mapped to human chromosome 1q43.
Immunogen
The antiserum was produced against synthesized peptide derived from human EXO1.
Immunogen Range: 61-110
Immunogen Range: 61-110
Application
Anti-EXO1 antibody produced in rabbit has been used in immunoblotting.
Biochem/physiol Actions
Exonuclease 1 (EXO1) N-domain mediates the DNA binding and the I domain is crucial for magnesium binding. It displays micro-mediated end-joining, 5′ to 3′ exonuclease activity and mediates homologous recombination and replication. EXO1 is more efficient on single-stranded DNA (ssDNA) than double-stranded DNA in exonucleolytic degradation. It also exhibits 5′ ssDNA-flap-specific endonuclease activity. EXO1 polymorphisms may be implicated in epithelial ovarian cancer (EOC).
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
常规特殊物品
低风险生物材料
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Human exonuclease 1 (EXO1) activity characterization and its function on flap structures.
Keijzers, et al.
Bioscience Reports, 35 (2018)
Tingyan Shi et al.
OncoTargets and therapy, 10, 4841-4851 (2017-10-19)
Exonuclease 1 (EXO1), one of DNA mismatch repair pathway genes, functions in maintaining genomic stability and affects tumor progression. We hypothesized that genetic variations in EXO1 may predict clinical outcomes in epithelial ovarian cancer (EOC). In this cohort study with
Mahmoud El-Shemerly et al.
Nucleic acids research, 36(2), 511-519 (2007-12-01)
Nucleases play important roles in DNA synthesis, recombination and repair. We have previously shown that human exonuclease 1 (hEXO1) is phosphorylated in response to agents stalling DNA replication and that hEXO1 consequently undergoes ubiquitination and degradation in a proteasome-dependent manner.
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SAB4503568-100UG | 04061837192784 |