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SAB4503615

Anti-EDG5 antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Endothelial differentiation G-protein coupled receptor 5, S1P receptor Edg-5, S1P2, Sphingosine 1-phosphate receptor 2, Sphingosine 1-phosphate receptor Edg-5

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About This Item

MDL number:
MFCD02686109
UNSPSC Code:
12352203
NACRES:
NA.41

Key Documents

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biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 38 kDa

species reactivity

rat, human, mouse

concentration

~1 mg/mL

technique(s)

ELISA: 1:40000
western blot: 1:500-1:1000

NCBI accession no.

O95136

UniProt accession no.

O95136

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... S1PR2(9294)

General description

Anti-EDG5 Antibody detects endogenous levels of total EDG5 protein.
EDG5/ S1PR2 (sphingosine-1-phosphate receptor 2), a pleiotropic lipid mediator is abundantly expressed in most of the tissues. S1PR2 codes for a 353 amino acid sphingosine-1-phosphate receptor 2 and is located on human chromosome 19p13.2.

Immunogen

The antiserum was produced against synthesized peptide derived from human EDG5.

Immunogen Range: 261-310

Biochem/physiol Actions

In NB (neuroblastoma), EDG5/ S1PR2 (sphingosine-1-phosphate receptor 2) helps in the expression of S1P-induced vascular endothelial growth factor. It promotes the Rho/Rho-kinase pathway. S1PR2 participates in S1P-induced platelet aggregation. S1PR2 is essential for normal auditory function as it is a part of the sphingosine-1-phosphate signaling (S1P) pathway.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
61237

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S1P2 receptor regulation of sphingosine-1-phosphate effects on conventional outflow physiology.
Sumida GM and Stamer WD
American Journal of Physiology. Cell Physiology, 300(5), C1164-C1171 (2011)
The conserved p. Arg108 residue in S1PR2 (DFNB68) is fundamental for proper hearing: evidence from a consanguineous Iranian family.
Hofrichter MA, et al.
BMC Medical Genetics, 19(1), 81-81 (2018)
Antitumor activity of a novel sphingosine-1-phosphate 2 antagonist, AB1, in neuroblastoma.
Li MH, et al.
Journal of Pharmacology and Experimental Therapeutics, 354(3), 261-268 (2015)
Voahanginirina Randriamboavonjy et al.
Basic research in cardiology, 104(3), 333-340 (2009-01-14)
Sphingosine-1-phosphate (S1P) is known to affect platelet responsiveness but the receptor mediating these effects and the mechanisms involved are poorly understood. This study was undertaken to examine S1P receptor expression in human platelets as well as potential changes associated with

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