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Merck
CN

SAB4503802

Anti-phospho-BTK (pTyr551) antibody produced in rabbit

affinity isolated antibody

Synonym(s):

Anti-AGMX1, Anti-AT, Anti-ATK, Anti-BPK, Anti-IGHD3, Anti-IMD1, Anti-PSCTK1, Anti-XLA

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA
western blot
Species reactivity:
rat, human, mouse
Citations:
3
Technique(s):
ELISA: 1:40000
western blot: 1:500-1:1000
Uniprot accession no.:
Q06187

Key Documents

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Product Name

Anti-phospho-BTK (pTyr551) antibody produced in rabbit, affinity isolated antibody

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 76 kDa

species reactivity

rat, human, mouse

concentration

~1 mg/mL

technique(s)

ELISA: 1:40000
western blot: 1:500-1:1000

NCBI accession no.

Q06187

UniProt accession no.

Q06187

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pTyr551)

Quality Level

100

Gene Information

human ... BTK(695)

Biochem/physiol Actions

Bruton tyrosine kinase (BTK) is a key element of B-cell–receptor signaling, which facilitates interactions with the tumor microenvironment and stimulates the survival and proliferation of chronic lymphocytic leukemia (CLL) cells. The encoded protein also plays a crucial role in activation of various constitutively active pathways of CLL-cell survival, such as the Akt, extracellular signal-regulated kinase (ERK) and nuclear factor κ light-chain enhancer of activated B cells (NF-κB) pathways. Additionally, it is also necessary for chemokine-mediated homing and adhesion of B cells. Polymorphisms in the gene are associated with the development of a symptomatic primary antibody deficiency (PAD), X-linked agammaglobulinemia.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

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General description

Bruton tyrosine kinase (BTK) is encoded by the gene mapped to human chromosome Xq22. The encoded protein belongs to the Tec family of kinases.

Immunogen

The antiserum was produced against synthesized peptide derived from human BTK around the phosphorylation site of Tyr551.

Immunogen Range: 516-565

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

常规特殊物品
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Certificates of Analysis (COA)

Lot/Batch Number
110055

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The lack of BTK does not impair monocytes and polymorphonuclear cells functions in X-linked agammaglobulinemia under treatment with intravenous immunoglobulin replacement
Cavaliere FM
PLoS ONE, 12 (2017)
Targeting BTK with Ibrutinib in Relapsed Chronic Lymphocytic Leukemia
Byrd JC
The New England Journal of Medicine, 369, 32-42 (2013)
Validation of the STR DXS7424 and the linkage situation on the X-chromosome.
Edelmann J
Forensic Science International, 125, 217-222 (2002)

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