SAB4503874
Anti-phospho-GR (pSer226) antibody produced in rabbit
affinity isolated antibody
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 85 kDa
species reactivity
mouse, rat, human
concentration
~1 mg/mL
technique(s)
ELISA: 1:5000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
phosphorylation (pSer226)
Gene Information
human ... GCR(2908)
Related Categories
General description
Glucocorticoid receptor (GR) gene/NR3C1 (nuclear receptor subfamily 3 group C member 1) is located on human chromosome 5q31. It belongs to the steroid receptor superfamily that has ligand-activated nuclear transcription factors.
Immunogen
The antiserum was produced against synthesized peptide derived from human GR around the phosphorylation site of Ser226.
Immunogen Range: 201-250
Immunogen Range: 201-250
Biochem/physiol Actions
The glucocorticoid receptor (GR) gene/(NR3C1) is associated with asthma. It is required for glucose homeostasis and has been associated with hyperinsulinemia and increased fat deposition. GR also regulates cell differentiation, nervous and immune system functions.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
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Multiple promoters exist in the human GR gene, one of which is activated by glucocorticoids
Breslin MB, et al.
Molecular Endocrinology, 15(8), 1381-1395 (2001)
Glucocorticoid receptor polymorphism in obesity and glucose homeostasis
Majer-Lobodzinska A and Adamiec-Mroczek J
Advances in Clinical and Experimental Medicine : Official Organ Wroclaw Medical University, 26(1), 143-148 (2017)
Alexander S Häusl et al.
Molecular psychiatry, 26(7), 3060-3076 (2021-03-03)
Disturbed activation or regulation of the stress response through the hypothalamic-pituitary-adrenal (HPA) axis is a fundamental component of multiple stress-related diseases, including psychiatric, metabolic, and immune disorders. The FK506 binding protein 51 (FKBP5) is a negative regulator of the glucocorticoid
Identification of polymorphisms in the human glucocorticoid receptor gene (NR3C1) in a multi-racial asthma case and control screening panel
Hawkins GA, et al.
Dna Sequence, 15(3), 167-173 (2004)
Structure of the glucocorticoid receptor (NR3C1) gene 5' untranslated region: identification, and tissue distribution of multiple new human exon 1
Turner JD and Muller CP
Journal of Molecular Endocrinology, 35(2), 283-292 (2005)
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