SAB4504012
Anti-phospho-ZAP-70 (pTyr315) antibody produced in rabbit
affinity isolated antibody
Sign In to View Organizational & Contract Pricing
Select a Size
About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 69 kDa
species reactivity
rat, human, mouse
concentration
~1 mg/mL
technique(s)
ELISA: 1:1000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
phosphorylation (pTyr315)
Gene Information
human ... ZAP70(7535)
General description
Zeta-chain-associated protein kinase 70 (ZAP70) is a tyrosine kinase, present in T cells and natural killer (NK) cells. It belongs to the spleen tyrosine kinase (Syk) family. This gene is mapped to human chromosome 2q11.
Immunogen
The antiserum was produced against synthesized peptide derived from human ZAP-70 around the phosphorylation site of Tyr315.
Immunogen Range: 281-330
Immunogen Range: 281-330
Biochem/physiol Actions
Zeta-chain-associated protein kinase 70 (ZAP70) plays an important role in T cell receptor (TCR) signaling. It acts as an adaptor protein to increase BCR (B-cell receptor) signaling. This protein is required for T-cell transendothelial migration mediated by C-X-C motif chemokine ligand 12.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Not finding the right product?
Try our Product Selector Tool.
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
常规特殊物品
This item has
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
An electrostatic selection mechanism controls sequential kinase signaling downstream of the T cell receptor
Shah N H, et al.
eLife (2016)
Mutations in Two Genes Encoding Different Subunits of a Receptor Signaling Complex Result in an Identical Disease Phenotype
Paloneva J, et al.
American Journal of Human Genetics, 71(3), 656-662 (2002)
The role of ZAP70 kinase in acute lymphoblastic leukemia infiltration into the central nervous system
Alsadeq A, et al.
Haematologica, 102(2), 346-355 (2017)
Imaging Spatiotemporal Activities of ZAP-70 in Live T Cells Using a FRET-Based Biosensor
Li K, et al.
Annals of Biomedical Engineering, 44(12), 3510-3521 (2016)
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service