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SAB4504254

Sigma-Aldrich

Anti-phospho-Kv1.3/KCNA3 (pTyr135) antibody produced in rabbit

affinity isolated antibody

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NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 58 kDa

species reactivity

mouse, rat, human

concentration

~1 mg/mL

technique(s)

ELISA: 1:20000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

NCBI accession no.

P22001

UniProt accession no.

P22001

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pTyr135)

Gene Information

human ... KCNA3(3738)

General description

The voltage-dependent potassium channel (Kv1.3/KCNA3) is expressed in the nervous and immune systems. This gene is located on human chromosome 1p13.

Immunogen

The antiserum was produced against synthesized peptide derived from human Kv1.3/KCNA3 around the phosphorylation site of Tyr135.

Immunogen Range: 101-150

Biochem/physiol Actions

The voltage-dependent potassium channel (Kv1.3/KCNA3) plays a major role in setting the resting membrane potential, cell proliferation, apoptosis and volume regulation. This protein participates in immunomodulation of autoreactive effector and memory T cell-mediated autoimmune diseases. KCNA3 is required for T-cell proliferation and activation.

Features and Benefits

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Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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The voltage-gated potassium channel Kv1. 3 is a promising multitherapeutic target against human pathologies.
Perez-Verdaguer M, et al.
Expert Opinion on Therapeutic Targets, 20(5), 577-591 (2016)
Inhibition of Kv1. 3 channels in human jurkat T cells by xanthohumol and isoxanthohumol.
Gasiorowska J, et al.
The Journal of Membrane Biology, 248(4), 705-711 (2015)
Polymorphism in the KCNA3 gene is associated with susceptibility to autoimmune pancreatitis in the Japanese population.
Ota M, et al.
Disease Markers, 31(4), 223-229 (2011)
Souvarish Sarkar et al.
The Journal of clinical investigation, 130(8), 4195-4212 (2020-07-01)
Characterization of the key cellular targets contributing to sustained microglial activation in neurodegenerative diseases, including Parkinson's disease (PD), and optimal modulation of these targets can provide potential treatments to halt disease progression. Here, we demonstrated that microglial Kv1.3, a voltage-gated

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