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Merck
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SAB4504264

Anti-phospho-RAD51 (pTyr315) antibody produced in rabbit

affinity isolated antibody

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203

Key Documents

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Product Name

Anti-phospho-RAD51 (pTyr315) antibody produced in rabbit, affinity isolated antibody

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 36 kDa

species reactivity

rat, human, mouse

concentration

~1 mg/mL

technique(s)

ELISA: 1:10000
western blot: 1:500-1:1000

NCBI accession no.

Q06609

UniProt accession no.

Q06609

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pTyr315)

Quality Level

100

Gene Information

human ... RAD51(5888)

Application

Anti-phospho-RAD51 (pTyr315) antibody has been used in western blotting.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)

Biochem/physiol Actions

RAD51 (RAD51 recombinase) plays a major role in homology-directed repair (HDR) and cell viability.This gene acts an an important target for cancer therapy. RAD51 interacts with BRCA2 (breast cancer susceptibility protein) and participates in DSB (double strand DNA breaks) repair.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

General description

RAD51 (RAD51 recombinase) belongs to the RecA/RadA/Rad51 protein family. It has a conserved ATP binding core. This protein is expressed in testis, ovary, and lymphoid tissue. It is located on human chromosome 15q15.

Immunogen

The antiserum was produced against synthesized peptide derived from human RAD51 around the phosphorylation site of Tyr315.

Immunogen Range: 281-330

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

常规特殊物品
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Certificates of Analysis (COA)

Lot/Batch Number
111117

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A cell-penetrating antibody inhibits human RAD51 via direct binding
Turchick A, et al.
Nucleic Acids Research, 45(20), 11782-11799 (2017)
Alteration/deficiency in activation-3 (Ada3) plays a critical role in maintaining genomic stability
Mirza S, et al.
Cell Cycle, 11(22), 4266-4274 (2012)
The Rad51/RadA N-terminal domain activates nucleoprotein filament ATPase activity.
Galkin VE, et al.
Structure, 14(6), 983-992 (2006)
Detection of loss of heterozygosity at RAD51, RAD52, RAD54 and BRCA1 and BRCA2 loci in breast cancer: pathological correlations.
Gonzalez R, et al.
British Journal of Cancer, 81(3), 503-509 (1999)
RAD51, BRCA2 and DNA repair: a partial resolution.
Lord CJ and Ashworth A
Nature Structural and Molecular Biology, 14(6), 461-462 (2007)
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