SAB4504264
Anti-phospho-RAD51 (pTyr315) antibody produced in rabbit
affinity isolated antibody
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 36 kDa
species reactivity
rat, human, mouse
concentration
~1 mg/mL
technique(s)
ELISA: 1:10000
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
phosphorylation (pTyr315)
Gene Information
human ... RAD51(5888)
General description
RAD51 (RAD51 recombinase) belongs to the RecA/RadA/Rad51 protein family. It has a conserved ATP binding core. This protein is expressed in testis, ovary, and lymphoid tissue. It is located on human chromosome 15q15.
Immunogen
The antiserum was produced against synthesized peptide derived from human RAD51 around the phosphorylation site of Tyr315.
Immunogen Range: 281-330
Immunogen Range: 281-330
Application
Anti-phospho-RAD51 (pTyr315) antibody has been used in western blotting.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Western Blotting (1 paper)
Biochem/physiol Actions
RAD51 (RAD51 recombinase) plays a major role in homology-directed repair (HDR) and cell viability.This gene acts an an important target for cancer therapy. RAD51 interacts with BRCA2 (breast cancer susceptibility protein) and participates in DSB (double strand DNA breaks) repair.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
常规特殊物品
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A cell-penetrating antibody inhibits human RAD51 via direct binding
Turchick A, et al.
Nucleic Acids Research, 45(20), 11782-11799 (2017)
Alteration/deficiency in activation-3 (Ada3) plays a critical role in maintaining genomic stability
Mirza S, et al.
Cell Cycle, 11(22), 4266-4274 (2012)
Detection of loss of heterozygosity at RAD51, RAD52, RAD54 and BRCA1 and BRCA2 loci in breast cancer: pathological correlations.
Gonzalez R, et al.
British Journal of Cancer, 81(3), 503-509 (1999)
The Rad51/RadA N-terminal domain activates nucleoprotein filament ATPase activity.
Galkin VE, et al.
Structure, 14(6), 983-992 (2006)
Human Rad51 protein promotes ATP-dependent homologous pairing and strand transfer reactions in vitro.
Baumann P, et al.
Cell, 87(4), 757-766 (1996)
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