SAB4504615
Anti-phospho-LATS1/2 (pThr1079/1041) antibody produced in rabbit
affinity isolated antibody
Synonym(s):
Anti-WARTS, Anti-wts
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, IHC
Citations:
7
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 126 kDa
species reactivity
mouse, rat, human
concentration
~1 mg/mL
technique(s)
ELISA: 1:20000, immunohistochemistry: 1:50-1:100
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
phosphorylation (pThr1079/pThr1041)
Quality Level
Gene Information
human ... LATS1(9113), LATS2(26524)
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General description
Large tumor suppressor kinase 1/ 2 (LATS1/2) is a mammalian homologue of the Drosophila tumor suppressor gene (lats)/warts. LATS1 and LATS2 are encoded by the gene mapped to human chromosomes 6q23-25.1 and 13q11–q12 respectively. hLATS2 is highly expressed in skeletal muscle and heart. LATS1 encodes a putative serine/threonine kinase.
Immunogen
The antiserum was produced against synthesized peptide derived from human LATS1/2 around the phosphorylation site of Thr1079/1041.
Immunogen Range: 1041-1090
Immunogen Range: 1041-1090
Biochem/physiol Actions
Large tumor suppressor kinase 1 (LATS1) and LATS2 are the key kinase constituents of the Hippo pathway. They play a vital role in the regulation of tumor progression and cell cycle, via various mechanisms and signaling pathways. LATS1 acts as a tumor suppressor in cervical cancer by regulating the expression of cyclin E, p27, matrix metalloproteinase 9 (MMP9) and yes-associated protein 1 (YAP). Overexpression of LATS2 leads to the development of acute myeloid leukemia (AML). Therefore, it is considered as a potential therapeutic target for AML treatment.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
常规特殊物品
低风险生物材料
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Molecular alterations of h-warts/LATS1 tumor suppressor in human soft tissue sarcoma.
Hisaoka M
Laboratory Investigation; a Journal of Technical Methods and Pathology, 82, 1427-1435 (2002)
Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/warts.
Yabuta N
Genomics, 63, 263-270 (2000)
The expression analysis of LATS2 gene in de novo AML patients.
Gholami M
Medical Oncology (Northwood, London, England), 31, 961-961 (2014)
LATS1 suppresses proliferation and invasion of cervical cancer
Molecular Medicine Reports, 15, 1654-1660 (2017)
Keishi Otsu et al.
Development (Cambridge, England), 148(4) (2021-01-22)
Stem cells are maintained in specific niches that strictly regulate their proliferation and differentiation for proper tissue regeneration and renewal. Molecular oxygen (O2) is an important component of the niche microenvironment, but little is known about how O2 governs epithelial
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