SAB4700290
Monoclonal Anti-CD42b antibody produced in mouse
clone HIP1, purified immunoglobulin, buffered aqueous solution
Synonym(s):
Anti-GP1BA, Anti-GPIb α
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Product Name
Monoclonal Anti-CD42b antibody produced in mouse, clone HIP1, purified immunoglobulin, buffered aqueous solution
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
HIP1, monoclonal
form
buffered aqueous solution
species reactivity
human, nonhuman primates
concentration
1 mg/mL
technique(s)
flow cytometry: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
2-8°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... GP1BA(2811)
Application
The reagent is designed for Flow Cytometry analysis. Suggested working dilution for Flow Cytometry is 2-8 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.
Biochem/physiol Actions
Cluster of differentiation 42b (CD42b) clustering promotes integrin αIIbβ3-dependent platelet aggregation, phagocytosis and rapid platelet clearance in the liver. The encoded protein acts as a platelet receptor for von Willebrand factor (VWF) and other ligands present in circulation. Mutation in the gene leads to autosomal recessive Bernard-Soulier syndrome. CD42b interacts with plasma hemoglobin (Hb) and enhances platelet activation and apoptosis in a concentration-dependent manner and also regulates platelet functions.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
Cluster of differentiation 42b (CD42b), also known as, glycoprotein Ib platelet α subunit (GP1BA), is encoded by the gene mapped to human chromosome 17p13.2.
The antibody HIP1 reacts with CD42b (GPIb alpha), a 135-145 kDa membrane glycoprotein expressed on platelets and megakaryocytes. CD42b and CD42c (GPIb beta) are composed in a disulfide linked heterodimer (CD42b/c; 160 kDa); CD42b/c forms a noncovalent complex with CD42a and CD42d.
Immunogen
Peripheral blood mononuclear cells of a patient suffering with CLL
Physical form
Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.
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Storage Class
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Hemoglobin interaction with GP1b? induces platelet activation and apoptosis: a novel mechanism associated with intravascular hemolysis
Singhal R
Haematologica, 100, 1526-1533 (2015)
Glycoprotein Ib? clustering induces macrophage-mediated platelet clearance in the liver.
Yan R
Thrombosis and Haemostasis, 113, 107-117 (2015)
Inhibiting GPIb? shedding preserves post-transfusion recovery and hemostatic function of platelets after prolonged storage
Chen W
Arteriosclerosis, Thrombosis, and Vascular Biology, 36, 1821-1828 (2016)
Genomic landscape of megakaryopoiesis and platelet function defects.
Elisa B, et al.
Blood, 127, 1249-1259 (2016)
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