SAB4700424
Monoclonal Anti-CD326-FITC antibody produced in mouse
clone VU-1D9, purified immunoglobulin, buffered aqueous solution
Synonym(s):
Anti-EPCAM
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About This Item
NACRES:
NA.44
UNSPSC Code:
12352203
Conjugate:
FITC conjugate
Clone:
VU-1D9, monoclonal
Application:
flow cytometry
Species reactivity:
human
Citations:
7
Technique(s):
flow cytometry: suitable
Uniprot accession no.:
Product Name
Monoclonal Anti-CD326-FITC antibody produced in mouse, clone VU-1D9, purified immunoglobulin, buffered aqueous solution
biological source
mouse
conjugate
FITC conjugate
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
VU-1D9, monoclonal
form
buffered aqueous solution
species reactivity
human
technique(s)
flow cytometry: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
2-8°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... EPCAM(4072)
Application
The reagent is designed for Flow Cytometry analysis of human blood cells using 20 μL reagent / 100 μL of whole blood or 1e6 cells in a suspension. The content of a vial (2 mL) is sufficient for 100 tests.
Biochem/physiol Actions
Cluster of differentiation 326 (CD326) is a transmembrane glycoprotein, involved in several cellular functions, such as epithelial-specific intercellular cell–adhesion, cell signaling, migration, proliferation and differentiation. CD326 is a dominant surface antigen mapped on human colon carcinoma. It has potential as a diagnostic marker for several carcinomas, including epithelial ovarian cancer (EOC). CD326 is considered to be a potential target for cancer treatment. CD326 with the help of components of wnt signal transduction pathway plays a vital role in stem cell signaling.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
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General description
Epithelial cell adhesion molecule (EpCAM) or cluster of differentiation 326 (CD326), is encoded by the 14kb GA733-2 gene mapped to human chromosome 2p21. Human CD326 expression is restricted to epithelia of colon, small intestine, lung, kidney, thymus, liver, pancreas, stomach. It is also expressed in several cancers, progenitor and stem cells. CD326 is a transmembrane glycoprotein characterized with an ectodomain, one transmembrane domain and a 26 residual cytoplasmic domain.
The mouse monoclonal antibody VU-1D9 recognizes an epitope within EGF-like domain I of CD326 / EpCAM, a marker of epithelial lineages. This antibody strongly stains various normal epithelial cells and carcinomas.
Immunogen
Small cell lung carcinoma cell line H69
Physical form
Solution in phosphate buffered saline containing 15 mM sodium azide and 0.2% high-grade protease free BSA as a stabilizing agent.
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Storage Class
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Epithelial cell adhesion molecule expression (CD326) in cancer: a short review.
Patriarca C
Cancer Treatment Reviews, 38, 68-75 (2012)
Graham Carpenter et al.
Cancer cell, 15(3), 165-166 (2009-03-03)
The epithelial-specific cell adhesion molecule (EpCAM) modulates cell adhesion and proliferation. Its overexpression correlates with tumor cell proliferation, and EpCAM is a therapeutic target. In the February issue of Nature Cell Biology, Maetzel et al. demonstrate that proliferative responses to
Monika Trzpis et al.
Transgenic research, 17(2), 229-238 (2007-10-18)
The Epithelial Cell Adhesion Molecule (EpCAM) is expressed virtually on normal epithelia in vertebrates. Among different species, the amino acid sequence of EpCAM is highly homologous, indicating that EpCAM is an evolutionary conserved protein. However, differences in the expression pattern
Markus Munz et al.
Cancer research, 69(14), 5627-5629 (2009-07-09)
Initially discovered as a dominant antigen on colon carcinomas, the epithelial cell adhesion molecule (EpCAM) was considered a mere cell adhesion molecule and reliable surface-binding site for therapeutic antibodies. Recent findings can better explain the relevance of EpCAM's high-level expression
Gilbert Spizzo et al.
Gynecologic oncology, 103(2), 483-488 (2006-05-09)
Currently available clinical and molecular factors provide still an insufficient prognostic and predictive assessment for patients with epithelial ovarian cancer (EOC). To identify a potential molecular target and prognostic/predictive factor for EOC, we investigated in a retrospective study the prognostic
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