SAB4700556
Monoclonal Anti-Cd4 azide free antibody produced in rat
clone GK1.5, purified immunoglobulin, buffered aqueous solution
Synonym(s):
Anti-CD4mut, Anti-IMD79, Anti-OKT4D
Sign In to View Organizational & Contract Pricing.
Select a Size
About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
GK1.5, monoclonal
Application:
FACS
Citations:
4
biological source
rat
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
GK1.5, monoclonal
form
buffered aqueous solution
species reactivity
mouse
concentration
1 mg/mL
technique(s)
flow cytometry: suitable
isotype
IgG2b
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
2-8°C
target post-translational modification
unmodified
Quality Level
Gene Information
mouse ... CD4(12504)
Related Categories
General description
Cluster of differentiation 4 (CD4) molecule is encoded by the gene mapped to human chromosome 12p13.31. The encoded protein is mainly localized on the surface of specific leukocytes. CD4 is characterized with a four ecto-domains (D1-D4) of which D1, D2 and D4 contain disulfide bonds.
The rat monoclonal antibody GK1.5 reacts with an extracellular epitope of mouse CD4 transmembrane glycoprotein (55 kDa).
Immunogen
Mouse CTL clone V4 cells
Application
The reagent is designed for Flow Cytometry analysis using 1 μg reagent / 1e6 cells in a suspension.
Biochem/physiol Actions
Cluster of differentiation 4 (CD4) facilitates the activation of immunostimulatory T-cells. It serves as a primary receptor for human immunodeficiency virus (HIV)-1 entry. The encoded protein also plays a key role in altering cell elasticity. Elevated expression of soluble CD4 has been observed in patients of infectious and chronic inflammatory diseases and rheumatoid arthritis (RA). Thus, this protein can be used as a potential diagnostic marker for the development of RA.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Solution in azide free phosphate buffered saline, pH 7.4; 0.2 um filter sterilized.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Not finding the right product?
Try our Product Selector Tool.
Storage Class
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
新产品
This item has
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Isochromosomes 12p and 9p: parental origin
and possible mechanisms of formation
Dutly F
European Journal of Human Genetics, 6, 140-144 (1998)
Human CD4 Metastability Is a Function of the Allosteric Disulfide Bond in Domain 2.
Owen GR
Biochemistry, 55, 2227-2237 (2016)
Disease severity in rheumatoid arthritis: relationships of plasma tumor necrosis factor-alpha, soluble interleukin 2-receptor, soluble CD4/CD8 ratio, neopterin, and fibrin D-dimer to traditional severity and functional measures.
Beckham JC
Journal of clinical immunology, 12, 353-361 (1992)
The role of CD4 on mechanical properties of live cell membrane.
Bui VC and Nguyen TH
Journal of Biomedical Materials Research Part A, 104, 239-244 (2016)
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service