Monoclonal Anti-Cd4 azide free antibody produced in rat

Cluster of differentiation 4 (CD4) molecule is encoded by the gene mapped to human chromosome 12p13.31. The encoded protein is mainly localized on the surface of specific leukocytes. CD4 is characterized with a four ecto-domains (D1-D4) of which D1, D2 and D4 contain disulfide bonds.

The rat monoclonal antibody GK1.5 reacts with an extracellular epitope of mouse CD4 transmembrane glycoprotein (55 kDa).

Mouse CTL clone V4 cells

The reagent is designed for Flow Cytometry analysis using 1 μg reagent / 1e6 cells in a suspension.

Cluster of differentiation 4 (CD4) facilitates the activation of immunostimulatory T-cells. It serves as a primary receptor for human immunodeficiency virus (HIV)-1 entry. The encoded protein also plays a key role in altering cell elasticity. Elevated expression of soluble CD4 has been observed in patients of infectious and chronic inflammatory diseases and rheumatoid arthritis (RA). Thus, this protein can be used as a potential diagnostic marker for the development of RA.

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Solution in azide free phosphate buffered saline, pH 7.4; 0.2 um filter sterilized.

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