SAB4700671
Monoclonal Anti-KRT18-Biotin antibody produced in mouse
clone DC-10, purified immunoglobulin, buffered aqueous solution
Synonym(s):
Anti-Cytokeratin 18
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
biotin conjugate
Clone:
DC-10, monoclonal
Application:
FACS
Citations:
5
biological source
mouse
Quality Level
conjugate
biotin conjugate
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
DC-10, monoclonal
form
buffered aqueous solution
species reactivity
human
concentration
1 mg/mL
technique(s)
flow cytometry: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
2-8°C
target post-translational modification
unmodified
Gene Information
human ... KRT18(3875)
General description
Keratin 18 (KRT 18) or cytokeratin 18 (CK18) encodes the type I intermediate filament chain keratin 18. The antibody DC-10 reacts with Cytokeratin 18 (45 kDa). Cytokeratins are a member of intermediate filaments subfamily represented in epithelial tissues. In human chromosome, the gene KRT18 is localized on 12q13.13.
Immunogen
Human breast carcinoma cell line PMC-42
Application
The reagent is designed for Flow Cytometry. Suggested working dilution is 1:500. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.
Biochem/physiol Actions
Keratin 18 (KRT18/CK18) pairs with CK8 to form the intermediate filaments and maintain the integrity in hepatocytes. CK18 associates with histone H3 in the progression of hepatocellular carcinoma (HCC). Disorganization or altered levels of CK18 is related to plectin deficiency in HCC. K18 may be a marker for liver diseases. K18 is present in Mallory bodies and is elevated in alcoholic cirrhosis and alcoholic hepatitis. K18 expression is modulated by interleukin 6 (IL-6). K18 interacts with desmosomal protein/ E-cadherin and promotes cell adhesion. CK18 is cleaved by caspases during apoptosis and released into blood as caspase cleaved cytokeratin-18 (CCCK18).
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.
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Storage Class
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Interleukin-6 Induces keratin expression in intestinal epithelial cells potential role of Keratin-8 in interleukin-6-induced barrier function alterations
Wang L, et al.
The Journal of Biological Chemistry, 282(11), 8219-8227 (2007)
Cytokeratin 18-associated Histone 3 Modulation in Hepatocellular Carcinoma: A Mini Review
Lai YCC, et al.
Cancer, Genomics, and Proteomics, 14(4), 219-223 (2017)
TP53 mutation, epithelial-mesenchymal transition, and stem like features in breast cancer subtypes
Coradini D, et al.
BioMed Research International, 2012 (2012)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SAB4700671-100UG | 04061829673123 |