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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
conjugate
unconjugated
antibody product type
primary antibodies
clone
H398, monoclonal
form
buffered aqueous solution
species reactivity
human
concentration
1 mg/ml
technique(s)
FUNC: suitable
flow cytometry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
isotype
IgG2a
UniProt accession no.
storage temp.
2-8°C
target post-translational modification
unmodified, unmodified
Quality Level
Gene Information
human ... TNFRSF1A(7132)
Biochem/physiol Actions
The mouse monoclonal antibody H398 recognizes the extracellular domain of CD120a, a 55 kDa receptor for tumor necrosis factor. The antibody blocks biological activity of both natural and recombinant human TNF alpha and TNF beta.
General description
CD120a / TNF R1, also known as TNFR55 or TNFRSF1A, is a 55 kDa receptor for tumor necrosis factor alpha and it is expressed in most tissues. By binding its trimeric ligand the CD120a protein forms trimers and the conformation change leads to dissociation of the inhibitory factor SODD from its intracellular death domain and in formation of signaling platform. CD120a can mediate apoptosis, and function as a regulator of inflammation. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease.
Immunogen
Recombinant full length human CD120a
Other Notes
The antibody solution should be gently mixed before use.
Physical form
Phosphate buffered saline (PBS), pH 7.4
Preparation Note
Purified by protein-A affinity chromatography.
Store at 2-8°C. Do not freeze.
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Storage Class
12 - Non Combustible Liquids
wgk
WGK 1
Regulatory Information
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