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Merck
CN

SAB4702055

Monoclonal Anti-CD63 Biotin produced in mouse

Synonym(s):

Granulophysin, LAMP-3, ME491, MLA1, OMA81H, TSPAN30, Tetraspanin-30, Tspan-30

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About This Item

UNSPSC Code:
12352203

Key Documents

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conjugate

biotin conjugate

Quality Level

100

antibody product type

primary antibodies

clone

MEM-259, monoclonal

form

buffered aqueous solution

species reactivity

human

concentration

1 mg/ml

technique(s)

flow cytometry: suitable
immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable

isotype

IgG1

UniProt accession no.

P08962

storage temp.

2-8°C

target post-translational modification

unmodified

Gene Information

human ... CD63(967)

General description

CD63 (LAMP-3, lysosome-associated membrane protein-3), a glycoprotein of tetraspanin family, is present in late endosomes, lysosomes and secretory vesicles of various cell types. It is also present in the plasma membrane, usually following cell activation. Hence, it has become an widely used basophil activation marker. In mast cells, however, CD63 exposition does not need their activation. CD63 interacts with integrins and affects phagocytosis and cell migration, it is also involved in H/K-ATPase trafficking regulation of ROMK1 channels. CD63 also serves as a T-cell costimulation molecule. Expression of CD63 can be used for predicting the prognosis in earlier stages of carcinomas.

Immunogen

HPB-ALL T cell line

Biochem/physiol Actions

The antibody MEM-259 reacts with an extracellular/luminal epitope of CD63 (LAMP-3), a 40-60 kDa tetraspan glycoprotein expressed by granulocytes, platelets, T cells, monocytes/macrophages and endothelial cells. Cell surface exposition of CD63 is usually activation-dependent.

Physical form

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Preparation Note

Purified antibody is conjugated with biotin LC-NHS ester under optimum conditions and unconjugated antibody and free biotin are removed by size-exclusion chromatography.
Store at 2-8°C. Do not freeze.

Other Notes

The antibody solution should be gently mixed before use.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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