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Merck
CN

SAB4702062

Monoclonal Anti-HLA-E purified produced in mouse

Synonym(s):

HLA class I histocompatibility antigen, MHC class I antigen E, alpha chain E

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About This Item

UNSPSC Code:
12352203

Key Documents

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conjugate

unconjugated

Quality Level

100

antibody product type

primary antibodies

clone

MEM-E/02, monoclonal

form

buffered aqueous solution

species reactivity

( Non-human primates), human

concentration

1 mg/ml

technique(s)

immunohistochemistry: suitable
western blot: suitable

isotype

IgG1

UniProt accession no.

P13747

storage temp.

2-8°C

target post-translational modification

unmodified, unmodified

Gene Information

human ... HLA-E(3133)

General description

HLA-E (human leukocyte antigen E) is a non-classical MHC I antigen, which is important for dialogue with NK cells and their regulation through interaction with CD94/NKG2 receptor. Like other MHC I molecules, transmembrane HLA-E molecule (45 kDa) associates with beta2 microglobulin. Unlike HLA-G, expression of HLA-E molecules is not so restricted, but it has been detected at least at mRNA level in virtually all cells and tissues examined. In peripheral blood, HLA-E protein is expressed at least in all mononuclear cells, but in different quantity (B cells and monocytes more than T cells and NK cells).

Immunogen

Recombinant human HLA-E denaturated heavy chain.

Biochem/physiol Actions

The antibody MEM-E/02 specifically reacts with an extracellular epitope on denaturated heavy chain of human HLA-E. HLA-E belongs to the MHC Class I molecules (MHC Class Ib; nonclassical) and it is expressed on the surface of all human cell types.

Physical form

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Preparation Note

Purified by protein-A affinity chromatography.
Store at 2-8°C. Do not freeze.

Other Notes

The antibody solution should be gently mixed before use.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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