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Merck
CN

SAB4702104

Monoclonal Anti-CD271, purified produced in mouse

Synonym(s):

NGFR, TNFRSF16, p75NGFR, p75NTR

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

Key Documents

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conjugate

unconjugated

antibody product type

primary antibodies

clone

NGFR5, monoclonal

form

buffered aqueous solution

species reactivity

human, ( Non-human primates), ( Rabbit), ( Cat)

concentration

1 mg/ml

technique(s)

flow cytometry: suitable
immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG1

UniProt accession no.

P08138

storage temp.

2-8°C

target post-translational modification

unmodified, unmodified

Quality Level

100

Gene Information

human ... NGFR(4804)

Biochem/physiol Actions

The mouse monoclonal antibody NGFR5 (originally C34C) recognizes an epitope within ammino acids 1 - 160 of CD271/NGFR, a 75 kDa transmembrane glycoprotein of the TNFR superfamily.

General description

CD271 / NGFR, also known as p75NGFR or p75NTR, is a 75 kDa low affinity receptor for the NGF (nerve growth factor), BDNF (brain-derived growth factor), and other neurotrophins, such as NT3 and NT4/5. Unlike other members of the tumor necrosis factor receptor superfamily of transmembrane proteins, CD271 has unique intracellular domain structure (lacks catalytic activity) and downstream signaling partners. Triggered by its ligands CD271 affects growth, differentiation, migration and death of the nervous system cells.

Immunogen

Purified CD271 protein isolated from human melanoma cell line A875

Other Notes

The antibody solution should be gently mixed before use.

Physical form

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Preparation Note

Purified by protein-A affinity chromatography.
Store at 2-8°C. Do not freeze.

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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