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Merck
CN

SAB5200020

Monoclonal Anti-MDC1 antibody produced in mouse

clone P2B11, 1 mg/mL, purified immunoglobulin

Synonym(s):

Anti-MDC1, P2B11, Anti-Nuclear factor with BRCT domains1, Anti-mediator of DNA damage checkpoint 1

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

Key Documents

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biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

P2B11, monoclonal

form

buffered aqueous glycerol solution

mol wt

antigen predicted mol wt 184 kDa

species reactivity

human, mouse, bovine, chimpanzee

concentration

1 mg/mL

technique(s)

indirect immunofluorescence: suitable
western blot: suitable

isotype

IgG1

NCBI accession no.

NP_001010833.2

UniProt accession no.

Q14676

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

mouse ... MDC1(240087)

General description

Mediator of DNA damage checkpoint 1 (MDC1) is a nuclear protein that in humans is encoded by the MDC1 gene mapped to chromosome 6p21.33. The encoded protein is widely expressed in various types of tissues and organs. MDC1 is characterized with two BRCA1 C terminus (BRCT) domain, an N-terminal phosphoamino-acid-binding motif called a forkhead-associated (FHA) domain and large central proline/serine/threonine-rich repeat (PST) domain.

Immunogen

GST-tagged recombinant protein corresponding to mouse MDC1 ar and around the N-termius

Biochem/physiol Actions

Detects ~184 kDa. This antibody recognizes MDC1 at and around the N-terminus.
Mediator of DNA damage checkpoint 1 (MDC1) plays a vital role in stimulation of the intra–S phase and G2-M phase checkpoints of the cell cycle in response to DNA damage. Polymorphism of the gene has been associated with the development of both the serum LDL-cholesterol concentration and hyper–LDL-cholesterolemia. Mammalian MDC1/ nuclear factor with BRCT domain 1 (NFBD1) interacts with phospho-H2AX (γH2AX) and plays a key role in DNA damage response by facilitating normal radioresistance and efficient accumulation of DNA-damage-response proteins on damaged chromatin.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Solution in PBS, pH 7.4, 50% glycerol, and 0.09% sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
1107

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MDC1 Directly Binds Phosphorylated Histone H2AX to Regulate Cellular Responses to DNA Double-Strand Breaks
Stucki M
Cell, 123, 1213-1226 (2005)
MDC1 is a mediator of the mammalian DNA damage checkpoint
Stewart GS
Nature, 421, 961-966 (2003)
Identification of eight genetic variants as novel determinants of dyslipidemia in Japanese by exome-wide association studies.
Yamada Y
Oncotarget, 8, 38950-38961 (2017)

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