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SAB5200035

Monoclonal Anti-HCN4 antibody produced in mouse

clone S114-10, 1 mg/mL, purified immunoglobulin

Synonym(s):

Anti-HCN4, S141-10, Anti-hyperpolarization activated cyclic nucleotide gated potassium channel 4

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
S114-10, monoclonal
Application:
immunocytochemistry
immunohistochemistry
western blot
Species reactivity:
rat, human, mouse
Citations:
16
Technique(s):
immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable
Uniprot accession no.:
Q9Y3Q4

Key Documents

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Product Name

Monoclonal Anti-HCN4 antibody produced in mouse, clone S114-10, 1 mg/mL, purified immunoglobulin

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

S114-10, monoclonal

form

buffered aqueous glycerol solution

mol wt

antigen predicted mol wt 130 kDa

species reactivity

rat, human, mouse

concentration

1 mg/mL

technique(s)

immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable

isotype

IgG1

NCBI accession no.

NP_067690.1

UniProt accession no.

Q9Y3Q4

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

rat ... HCN4(59266)

Related Categories

Biochem/physiol Actions

Detects ~130 kDa. No cross-reactivity against other HCNs

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

General description

Hyperpolarization activated cyclic nucleotide-gated potassium channel 4 (HCN4) is one of the subunits of hyperpolarization-activated cyclic nucleotide-gated channels, which have a role in synaptic transmission, dendritic integration, membrane and action potential. It is a heteromeric channel. HCN4 is highly expressed in rat embryonic hearts, specifically in the sinoatrial node.

Immunogen

Fusion protein amino acids 1019-1198 (c-terminus) of rat HCN4, Accession Number Q9JKA7

Physical form

Solution in PBS, pH 7.4, 50% glycerol, and 0.09% sodium azide

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Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

常规特殊物品
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Certificates of Analysis (COA)

Lot/Batch Number
MH587202

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HCN4 subunit expression in fast-spiking interneurons of the rat spinal cord and hippocampus.
Hughes DI
Neuroscience (2013)
Valentina Prando et al.
The Journal of physiology, 596(11), 2055-2075 (2018-03-11)
The present study demonstrates, by in vitro and in vivo analyses, the novel concept that signal transmission between sympathetic neurons and the heart, underlying the physiological regulation of cardiac function, operates in a quasi-synaptic fashion. This is a result of
Associated changes in HCN2 and HCN4 transcripts and I(f) pacemaker current in myocytes.
Zhang Q
Biochimica et Biophysica Acta (2009)
NRSF regulates the developmental and hypertrophic changes of HCN4 transcription in rat cardiac myocytes.
Biochemical and Biophysical Research Communications (2007)
Victor Naumov et al.
Journal of neurophysiology, 121(6), 2126-2139 (2019-04-04)
The inferior colliculus (IC) is a large midbrain nucleus that integrates inputs from many auditory brainstem and cortical structures. Despite its prominent role in auditory processing, the various cell types and their connections within the IC are not well characterized.
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