SAB5200080
Monoclonal Anti-ITPR1 antibody produced in mouse
clone S24-18, 1 mg/mL, purified immunoglobulin
Synonym(s):
Anti-IP3 Receptor
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
S24-18, monoclonal
Application:
IHC, IP, WB
Citations:
4
biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
S24-18, monoclonal
form
buffered aqueous glycerol solution
mol wt
antigen predicted mol wt 300 kDa
species reactivity
human, mouse, rat
concentration
1 mg/mL
technique(s)
immunohistochemistry: suitable, immunoprecipitation (IP): suitable, western blot: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
rat ... Itpr1(25262)
General description
Inositol 1,4,5-trisphosphate receptor, type 1 (ITPR1) is highly expressed in the rat brain and is also seen in the heart. It possesses an inositol-triphosphate binding domain, a channel-forming region and a regulatory region. ITPR1 is composed of 2749 amino acids. The gene ID for the protein is 25262.
Immunogen
Fusion protein amino acids 2680-2749 (cytoplasmic carboxyl terminus) of rat type1 IP3R inositol 1,4,5-triphosphate receptor type 1, Itpr1
Application
Monoclonal Anti-ITPR1 antibody produced in mouse has been used for Western blotting.
Biochem/physiol Actions
Detects ~300 kDa. Does not recognize type 2 or type 3 IP3R′s.
Inositol 1,4,5-trisphosphate receptor, type 1 (ITPR1) takes part in Ca2+ signaling on binding to its ligand, inositol 1,4,5-trisphosphate.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Solution in PBS, pH 7.4, 50% glycerol, and 0.09% sodium azide
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Krishna P Subedi et al.
Cellular & molecular biology letters, 17(1), 124-135 (2011-12-31)
Inositol 1,4,5-trisphosphate receptor type 1 (IP(3)R1) is already known to be highly expressed in the brain, and is found in many other tissues, including the atrium of the heart. Although the complete primary structure of IP(3)R1 in the rat brain
Calcium signalling from the type I inositol 1,4,5-trisphosphate receptor is required at early phase of liver regeneration.
Oliveira AG
Liver International : Official Journal of the International Association For the Study of the Liver, 35(4), 1162-1171 (2015)
Yi Sun et al.
The Biochemical journal, 449(1), 39-49 (2012-09-27)
Binding of IP3 (inositol 1,4,5-trisphosphate) to the IP3-binding core (residues 224-604) of IP3Rs (IP3 receptors) initiates opening of these ubiquitous intracellular Ca2+ channels. The mechanisms are unresolved, but require conformational changes to pass through the suppressor domain (residues 1-223). A
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SAB5200080-100UG | 04061838058942 |