Key Documents

View All Documentation

SAB5200113

Anti-Amyloid Precursor Protein (APP) Antibody

Name: Anti-Amyloid Precursor Protein (APP) Antibody
Brand: SIGMA

rabbit polyclonal

Synonym(s):

Anti-A11, Anti-Amyloid Oligomer αβ, Anti-Amyloid Oligomers (A11)

Select a Size

Change View

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

Conjugate:

unconjugated

Clone:

polyclonal

Application:

ELISA (i), IF, IHC, IP, WB

Citations:

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Properties

Product Name

Anti-APP antibody produced in rabbit, 1 mg/mL, affinity isolated antibody

biological source

rabbit

Quality Segment

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous glycerol solution

species reactivity

mouse, eukaryotes, rat, human

concentration

1 mg/mL

technique(s)

immunohistochemistry: suitable, immunoprecipitation (IP): suitable, indirect ELISA: suitable, indirect immunofluorescence: suitable, western blot: suitable

NCBI accession no.

NM_000484.2

UniProt accession no.

P05067

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... APP(351)

Description

General description

Amyloid β precursor protein (APP) is a type 1 transmembrane protein. The gene is located on human chromosome 21q21.3.

Immunogen

Synthetic molecular mimic of soluble oligomers.

Application

Anti-APP antibody produced in rabbit has been used in western blotting.

Biochem/physiol Actions

Amyloid β precursor protein (APP) regulates cell signaling. Mutation in this gene is associated with Alzheimer′s disease. It is implicated in synaptic plasticity, dendritic morphogenesis and neuroprotection. APP modulates synaptic vesicle proteins and synaptic transmission. It is involved in GABAergic transmission and maintains the excitatory/inhibitory (E/I) balance.

Amyloid precursor protein (APP) plays a key role in Wnt signalling. It helps to increase synaptoxicity, that is facilitated by Dickkopf-1 (Dkk1). Mutations on this gene results in autosomal dominant early-onset Alzheimer disease (ADEOAD)/hereditary dementia with cerebral amyloid angiopathy (CAA).

Recognizes all types of amyloid oligomers. Appears to recognize a peptide backbone epitope that is common to amyloid oligomers, but is not found in native proteins, amyloidogenic monomer or mature amyloid fibrils.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

PBS, 50% glycerol, and 0.09% sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Still not finding the right product?

Explore all of our products under Anti-APP antibody produced in rabbit

— or —

Try our Product Selector Tool to narrow your options

Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c