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Merck
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SAB5200921

Monoclonal Anti-Notch1 - Percp antibody produced in mouse

clone S253-32, purified immunoglobulin

Synonym(s):

Anti-Motch, Anti-Neurogenic locus notch homolog protein 1, Anti-Neurogenic locus notch protein homolog, Anti-TAN1

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
Peridinin-Chlorophyll-Protein Complex
Clone:
S253-32, monoclonal
Application:
ICC, WB
Citations:
5

Key Documents

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biological source

mouse

conjugate

Peridinin-Chlorophyll-Protein Complex

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

S253-32, monoclonal

form

buffered aqueous solution

mol wt

antigen predicted mol wt >270, ~120 kDa

species reactivity

mouse, rat, human

concentration

1 mg/mL

technique(s)

immunocytochemistry: suitable, western blot: suitable

isotype

IgG1

NCBI accession no.

NP_032740.3

UniProt accession no.

Q07008

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

mouse ... Notch1(18128)

General description

The NOTCH1 gene is mapped to human chromosome 9q34.3. In mice, Notch1 is highly expressed in immature neurons of hippocampus. Notch1 is localized to renal epithelial cells and podocytes of metanephros.

Immunogen

Fusion protein amino acids 20-216 (extracellular N-terminus, EGF-like domains 1-5) of mouse Notch1

Biochem/physiol Actions

The Notch signaling pathway regulates endothelial-cell differentiation, proliferation and apoptosis, and is essential for the development, maintenance and remodeling of the vascular system. Notch signaling pathway is involved in the development and progress of cardiovascular diseases. Notch1 function is predominant in developing kidney compared to compared to the mature organ.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

PBS pH7.4, 50% glycerol, 0.09% sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Evolutionary significance of intra-genome duplications on human chromosomes.
Endo T, et al.
Gene, 205(1), 19-27 (1997)
Phospholipase Cγ1 Mediates Intima Formation Through Akt?Notch1 Signaling Independent of the Phospholipase Activity.
Jiang D, et al.
Journal of the American Heart Association, 6(7), e005537-e005537 (2017)
Autophagy is involved in mouse kidney development and podocyte differentiation regulated by Notch signalling.
Zhang C, et al.
Journal of Cellular and Molecular Medicine, 21(7), 1315-1328 (2017)
Simvastatin enhances bone marrow stromal cell differentiation into endothelial cells via notch signaling pathway
Xu J, et al.
American Journal of Physiology. Cell Physiology, 296(3), C535-C543 (2009)
Postnatal dysregulation of Notch signal disrupts dendrite development of adult-born neurons in the hippocampus and contributes to memory impairment.
Ding X F, et al.
Scientific Reports, 6, 25780-25780 (2016)

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