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SAB5300151

Monoclonal Anti-AIFM1 antibody produced in mouse

clone 4E7, ascites fluid

Synonym(s):

AIF, AIFM1, COXPD6, MGC111425, PDCD8

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
4E7, monoclonal
Application:
ELISA (d), FACS, IF, IHC, WB
Citations:
4

Key Documents

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biological source

mouse

conjugate

unconjugated

antibody form

ascites fluid

antibody product type

primary antibodies

clone

4E7, monoclonal

mol wt

67 kDa

species reactivity

mouse, monkey, human, rat

technique(s)

direct ELISA: 1:10,000, flow cytometry: 1:200-1:400, immunohistochemistry: 1:200-1:1,000, indirect immunofluorescence: 1:200-1:1,000, western blot: 1:500-1:2,000

isotype

IgG2b

NCBI accession no.

NM_001130846

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... AIF(9131)

Related Categories

General description

AIFM1 (apoptosis inducing factor mitochondria associated 1) codes for apoptosis-inducing factor 1(AIF). It is located on human chromosome Xq26.1. AIF is a caspase-independent cell death effector.

Immunogen

Purified recombinant fragment of human AIF expressed in E.coli.
Mouse monoclonal antibody raised against AIF

Biochem/physiol Actions

AIFM1 (apoptosis inducing factor mitochondria associated 1) possesses redox activity, which helps in oxidative phosphorylation. In the mitochondria, AIFM1 helps in assembling or maintaining the mitochondrial respiratory complexes I and III. It plays a vital role in apoptosis. This gene is associated with COXPD6 (combined oxidative phosphorylation deficiency, encephalomyopathy, Cowchock syndrome and X-linked deafness with neuropathy.

Physical form

Ascitic fluid containing 0.03% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

动植物来源生物产品
常规特殊物品
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Certificates of Analysis (COA)

Lot/Batch Number
PM12083122

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Influenza virus infection induces translocation of apoptosis-inducing factor (AIF) in A549 cells: role of AIF in apoptosis and viral propagation.
Qu X, et al.
Archives of Virology, 162(3), 669-675 (2017)
Spondyloepimetaphyseal dysplasia with neurodegeneration associated with AIFM1 mutation?a novel phenotype of the mitochondrial disease.
Mierzewska H, et al.
Clinical Genetics, 91(1), 30-37 (2017)
X-linked hypomyelination with spondylometaphyseal dysplasia (H-SMD) associated with mutations in AIFM1.
Noriko M, et al.
Neurogenetics, 18(4), 185?194-185?194 (2017)
A newly distal hereditary motor neuropathy caused by a rare AIFM1 mutation.
Sancho P, et al.
Neurogenetics, 18(4), 245-250 (2017)

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