SAB5300151
Monoclonal Anti-AIFM1 antibody produced in mouse
clone 4E7, ascites fluid
别名:
AIF, AIFM1, COXPD6, MGC111425, PDCD8
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
4E7, monoclonal
Application:
ELISA (d), FACS, IF, IHC, WB
Citations:
4
biological source
mouse
conjugate
unconjugated
antibody form
ascites fluid
antibody product type
primary antibodies
clone
4E7, monoclonal
mol wt
67 kDa
species reactivity
mouse, monkey, human, rat
technique(s)
direct ELISA: 1:10,000, flow cytometry: 1:200-1:400, immunohistochemistry: 1:200-1:1,000, indirect immunofluorescence: 1:200-1:1,000, western blot: 1:500-1:2,000
isotype
IgG2b
NCBI accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... AIF(9131)
General description
AIFM1 (apoptosis inducing factor mitochondria associated 1) codes for apoptosis-inducing factor 1(AIF). It is located on human chromosome Xq26.1. AIF is a caspase-independent cell death effector.
Immunogen
Purified recombinant fragment of human AIF expressed in E.coli.
Mouse monoclonal antibody raised against AIF
Mouse monoclonal antibody raised against AIF
Biochem/physiol Actions
AIFM1 (apoptosis inducing factor mitochondria associated 1) possesses redox activity, which helps in oxidative phosphorylation. In the mitochondria, AIFM1 helps in assembling or maintaining the mitochondrial respiratory complexes I and III. It plays a vital role in apoptosis. This gene is associated with COXPD6 (combined oxidative phosphorylation deficiency, encephalomyopathy, Cowchock syndrome and X-linked deafness with neuropathy.
Physical form
Ascitic fluid containing 0.03% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
动植物来源生物产品
常规特殊物品
此项目有
Influenza virus infection induces translocation of apoptosis-inducing factor (AIF) in A549 cells: role of AIF in apoptosis and viral propagation.
Qu X, et al.
Archives of Virology, 162(3), 669-675 (2017)
Spondyloepimetaphyseal dysplasia with neurodegeneration associated with AIFM1 mutation?a novel phenotype of the mitochondrial disease.
Mierzewska H, et al.
Clinical Genetics, 91(1), 30-37 (2017)
X-linked hypomyelination with spondylometaphyseal dysplasia (H-SMD) associated with mutations in AIFM1.
Noriko M, et al.
Neurogenetics, 18(4), 185?194-185?194 (2017)
A newly distal hereditary motor neuropathy caused by a rare AIFM1 mutation.
Sancho P, et al.
Neurogenetics, 18(4), 245-250 (2017)
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