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SAB5300203

Monoclonal Anti-SMN1 antibody produced in mouse

clone 2F1, ascites fluid

Synonym(s):

SMA, SMA1, SMA2, SMA3, SMN

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
2F1, monoclonal
Application:
direct ELISA
flow cytometry
immunohistochemistry
western blot
Species reactivity:
monkey, human
Citations:
6
Technique(s):
direct ELISA: 1:10,000
flow cytometry: 1:200-1:400
immunohistochemistry: 1:200-1:1,000
western blot: 1:500-1:2,000

Key Documents

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Product Name

Monoclonal Anti-SMN1 antibody produced in mouse, clone 2F1, ascites fluid

biological source

mouse

conjugate

unconjugated

antibody form

ascites fluid

antibody product type

primary antibodies

clone

2F1, monoclonal

mol wt

39 kDa

species reactivity

monkey, human

technique(s)

direct ELISA: 1:10,000
flow cytometry: 1:200-1:400
immunohistochemistry: 1:200-1:1,000
western blot: 1:500-1:2,000

isotype

IgG1

NCBI accession no.

NM_000344.3

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... SMN1(6606)

Related Categories

Biochem/physiol Actions

Survival motor neuron 1 (SMN1) is involved in the synthesis of full length survival motor neuron (SMN) mRNA transcripts. SMN1 also contributes to the biogenesis and assembly of snRNP (small nuclear riboproteins) in the cytoplasm, which plays an important role in pre-mRNA splicing or processing. Axonal SMN protein mediates the growth of axon and mRNA axonal transport. Mutations in the SMN1 gene has been associated with a genetic neurodegenerative disease called spinal muscular atrophy(SMA).

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Survival motor neuron 1 (SMN1), also known as gemin 1, is a survival motor neuron protein, which is highly expressed in spinal cord. SMN1 is localized on the telomeric region of human chromosome 5q13. The 38kDA protein is expressed mostly in nucleus and cytoplasm.

Immunogen

Purified recombinant fragment of human SMN1 expressed in E.coli.
Mouse monoclonal antibody raised against SMN1

Physical form

Ascitic fluid containing 0.03% sodium azide.

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Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
1106211
PM1106211

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Identification and characterization of a spinal muscular atrophy-determining gene
Lefebvre S, et al.
Cell, 80(1), 155-165 (1995)
How do SMA-linked mutations of SMN1 lead to structural/functional deficiency of the SMA protein?
Li W
PLoS ONE, 12(6), e0178519-e0178519 (2017)
SMN affects membrane remodelling and anchoring of the protein synthesis machinery
Francesca G, et al.
Journal of Cell Science, jcs-176750 (2016)
Different stability and proteasome-mediated degradation rate of SMN protein isoforms
Locatelli D, et al.
PLoS ONE, 10(7), e0134163-e0134163 (2015)
SMN regulation in SMA and in response to stress: new paradigms and therapeutic possibilities
Dominguez CE, et al.
Human Genetics, 136(9), 1173-1191 (2017)
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