SAB5500082
Anti-Chromogranin A antibody, Rabbit monoclonal
recombinant, expressed in proprietary host, clone SP12, tissue culture supernatant
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
SP12, monoclonal
Application:
immunohistochemistry
Species reactivity:
human (tested)
Citations:
3
Technique(s):
immunohistochemistry: 1:200
Uniprot accession no.:
Product Name
Anti-Chromogranin A antibody, Rabbit monoclonal, recombinant, expressed in proprietary host, clone SP12, tissue culture supernatant
biological source
rabbit
recombinant
expressed in proprietary host
conjugate
unconjugated
antibody form
tissue culture supernatant
antibody product type
primary antibodies
clone
SP12, monoclonal
species reactivity
human (tested)
species reactivity (predicted by homology)
bovine, pig
technique(s)
immunohistochemistry: 1:200
isotype
IgG
UniProt accession no.
shipped in
wet ice
storage temp.
2-8°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... CHGA(1113)
Biochem/physiol Actions
Chromogranin A (CgA) controls vascular physiology and angiogenesis. It modulates the storage and liberation of catecholamine via intracellular (vesiculogenic) and extracellular (catecholamine release–inhibitory) mechanisms. CHGA is essential to generate catecholamine secretory vesicles in chromaffin-lineage PC12 cells and is required to promote a regulated secretion system in nonsecretory cells.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
Chromogranin A (CgA) is a circulating protein liberated by the neuroendocrine system. It is a glycoprotein that is located on human chromosome 14.
Chromogranin A (a protein of 439 amino acid which is encoded on chromosome 14) is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets. It is an excellent marker for carcinoid tumors, phenochromocytomas, paragangliomas, and other neuroendocrine tumors. Coexpression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms.
Immunogen
Recombinant protein encoding human chromogranin A.
Physical form
0.1 ml rabbit monoclonal antibody supplied as tissue culture supernatant in TBS/1% BSA buffer pH 7.5 with less than 0.1% sodium azide.
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Storage Class
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Find documentation for the products that you have recently purchased in the Document Library.
The human chromogranin A gene: chromosome assignment and RFLP analysis.
Modi WS, et al.
American Journal of Human Genetics, 45(5), 814-814 (1989)
Plasma levels of vasostatin-1, a chromogranin A fragment, are associated with carotid artery maximum stenosis: A pilot study.
Bachetti T, et al.
International Journal of Cardiology, 236, 438-443 (2017)
Both rare and common polymorphisms contribute functional variation at CHGA, a regulator of catecholamine physiology.
Wen G, et al.
American Journal of Human Genetics, 74(2), 197-207 (2004)
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