SAB5500135
Anti-KU80 antibody, Rabbit monoclonal
recombinant, expressed in proprietary host, clone SP130, affinity isolated antibody
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
SP130, monoclonal
Application:
IHC
Citations:
-
biological source
rabbit
recombinant
expressed in proprietary host
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
SP130, monoclonal
species reactivity
human (tested)
species reactivity (predicted by homology)
bovine, rat, mouse
technique(s)
immunoblotting: 1:25, immunohistochemistry: 1:100
isotype
IgG
UniProt accession no.
shipped in
wet ice
storage temp.
2-8°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... XRCC5(7520)
General description
X-ray repair cross-complementing protein 5 (XRCC5), alternative name (Ku80), is single stranded DNA-dependent ATP-dependent helicase. It involves in chromosome translocation. Ku80 along with Ku70 forms a heterodimeric protein originally identified as autoantigens associated with several autoimmune diseases including scleroderma, polymyositis and systemic lupus erythematosus. Ku is widely expressed nuclear protein that binds to and stabilizes the ends of DNA at telomeres or double-stranded DNA breaks. The inhibition of Ku80 can damage the DNA repair pathway of tumor cells and potentially increase the killing of cancer cells, and reduce drug resistance.
Immunogen
Synthetic peptide corresponding to an internal region within Human Ku80 aa 700 to the C-terminus.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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