SAB5500140
Anti-MAGE-A1 antibody, Rabbit monoclonal
recombinant, expressed in proprietary host, clone SP194, affinity isolated antibody
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
SP194, monoclonal
Application:
FACS, IHC
Citations:
2
biological source
rabbit
recombinant
expressed in proprietary host
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
SP194, monoclonal
species reactivity
human (tested)
technique(s)
flow cytometry: 1:400, immunoblotting: 1:400, immunohistochemistry: 1:100
isotype
IgG
UniProt accession no.
shipped in
wet ice
storage temp.
2-8°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... MAGEA1(4100)
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General description
Melanoma-associated antigen 1 (MAGE-A1) belongs to the melanoma-associated antigen (MAGE) gene family. It is also termed cancer-testis antigen (CTA) or cancer-germline (CG) gene. The MAGE-A1 gene is mostly expressed in the human germline. It is also expressed in the placenta and various tumor cells. MAGE-A1 gene is located on human chromosome Xq28.
Immunogen
Synthetic peptide derived from the C-terminus of human MAGE-A1 protein.
Biochem/physiol Actions
Melanoma-associated antigen 1 (MAGE-A1) stimulates the proliferation and colony formation of melanoma cells. It might modulate the oncogenic C-JUN expression either directly or via the extracellular-signal-regulated kinase (ERK)-mitogen-activated protein kinase (MAPK) signaling pathway. Hence, MAGE-A1 could be a possible therapeutic target for patients with melanoma. It can be a potential marker in the treatment of lung adenocarcinoma (LUAD).
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Dong Wang et al.
Biochemical and biophysical research communications, 473(4), 959-965 (2016-04-06)
MAGE-A1 belongs to the chromosome X-clustered genes of cancer-testis antigen family and is normally expressed in the human germ line but is also overexpressed in various tumors. Previous studies of MAGE-A1 in melanoma mainly focused on methylation changes or its
Yuan Mao et al.
Journal of hematology & oncology, 12(1), 106-106 (2019-10-24)
Cancer/testis antigens (CTAs) are a special type of tumor antigen and are believed to act as potential targets for cancer immunotherapy. In this study, we first screened a rational CTA MAGE-A1 for lung adenocarcinoma (LUAD) and explored the detailed characteristics
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