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Merck
CN

SAB5500164

Anti-PLAP antibody, Rabbit monoclonal

recombinant, expressed in proprietary host, clone SP15, tissue culture supernatant

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203

Key Documents

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Product Name

Anti-PLAP antibody, Rabbit monoclonal, recombinant, expressed in proprietary host, clone SP15, tissue culture supernatant

biological source

rabbit

recombinant

expressed in proprietary host

conjugate

unconjugated

antibody form

tissue culture supernatant

antibody product type

primary antibodies

clone

SP15, monoclonal

species reactivity

human (tested)

technique(s)

immunohistochemistry: 1:100

isotype

IgG

UniProt accession no.

P05187

shipped in

wet ice

storage temp.

2-8°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... ALPP(250)

Biochem/physiol Actions

Placental alkaline phosphatase (PLAP) or ALPP is a hydrolase, which is involved in the hydrolysis of phosphomonoesters. It has been shown to be a biomarker for ovarian cancer. The protein is expressed in carcinomas such as ovarian adenocarcinoma, dysgerminoma, serous cystadenocarcinoma and undifferentiated carcinoma.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

General description

Placental alkaline phosphatase (PLAP) or ALPP is a phosphomonoesterase. It is expressed in the placenta and endometrium. The PLAP gene is localized on human chromosome 2q37.1.

Immunogen

Recombinant protein encoding human placental alkaline phosphatase.

Physical form

0.1 ml rabbit monoclonal antibody supplied as tissue culture supernatant in TBS/1% BSA buffer pH 7.5 with less than 0.1% sodium azide.

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Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
GR34001111
GR34316901

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Human placental alkaline phosphatase-mediated hydrolysis correlates tightly with the electrostatic contribution from tail group.
Yang Y
Chemical Biology & Drug Design (2011)
Genome wide expression profile in human HTR-8/Svneo trophoblastic cells in response to overexpression of placental alkaline phosphatase gene.
Bellazi L
Placenta (2011)
Cloverleaf skull anomaly and de novo
trisomy 4p
Journal of medical Genetics (1999)
Refined structures of placental alkaline phosphatase show a consistent pattern of interactions at the peripheral site.
Stec B
Acta Crystallographica Section F, Structural Biology and Crystallization Communications (2010)
A human monoclonal antibody specific to placental alkaline phosphatase, a marker of ovarian cancer.
Ravenni N
MAbs (2014)

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