SAB5600038
Anti-Gamma H2AX (phospho-Ser139) antibody, Rabbit monoclonal
recombinant, expressed in HEK 293 cells, clone RM224, purified immunoglobulin
Synonym(s):
H2AX Ser139 p, Histone H2AX (phospho ser139)
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Clone:
RM224, monoclonal, recombinant monoclonal
Species reactivity:
human
Application:
ELISA, ICC
Citations:
6
recombinant
expressed in HEK 293 cells
Quality Level
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
RM224, monoclonal, recombinant monoclonal
form
buffered aqueous glycerol solution
species reactivity
human
concentration
~1 mg/mL
technique(s)
ELISA: 0.2- 1 μg/mL, immunoblotting: 0.5-2 μg/mL, immunocytochemistry: 0.5-2 μg/mL
isotype
IgG
NCBI accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
phosphorylation (pSer139)
Gene Information
human ... H2AX(3014)
General description
Histone H2AX (H2A histone family member X), a histone variant present in almost all eukaryotes, is coded by H2AFX gene. It is mapped to human chromosome 11q23.2–11q23.3.
Immunogen
Synthetic peptide corresponding to Phospho-Histone H2AX (Ser139)
Biochem/physiol Actions
H2AX (H2A histone family member X) helps to maintain genome stability. It plays an important role in localisation and structuring of the repair focus. H2AX also plays an active role in supplying the active repair proteins. γH2AX participates in DSB repair. This protein serves as a signal and target of phosphorylation in the spreading phase.
This antibody reacts to Histone H2A.X only when phosphorylated at serine 139. No cross reactivity with other phosphorylated histones.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Solution in phosphate buffered saline containing 50% glycerol, 1% BSA and 0.09% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
低风险生物材料
常规特殊物品
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Dong Luo et al.
ACS applied materials & interfaces, 14(13), 14916-14927 (2022-03-23)
Combined radiotherapy (RT) and chemotherapy are prescribed to patients with advanced prostate cancer (PCa) to increase their survival; however, radiation-related side effects and systematic toxicity caused by chemotherapeutic drugs are unavoidable. To improve the precision and efficacy of concurrent RT
Roisin M McAvera et al.
Scientific reports, 14(1), 8797-8797 (2024-04-17)
Deletions of chromosome 1p (del(1p)) are a recurrent genomic aberration associated with poor outcome in Multiple myeloma (MM.) TRIM33, an E3 ligase and transcriptional co-repressor, is located within a commonly deleted region at 1p13.2. TRIM33 is reported to play a
Gulam Mohmad Rather et al.
Cancers, 13(5) (2021-03-04)
We tested the antitumor effects of a modified E2F peptide substituting D-Arg for L-Arg, conjugated to penetratin (PEP) against solid tumor cell lines and the CCRF-leukemia cell line, alone and in combination with pemetrexed or with cisplatin. For in-vivo studies
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SAB5600038-100UG | 04061831498271 |