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SAB5700562

Sigma-Aldrich

Anti-Phospho-GRIN2B-Y1070 antibody produced in rabbit

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Synonym(s):
EIEE27, GRIN2B, GluN2B, MRD6, NMDAR2B, NR2B, hNR3

biological source

rabbit

Quality Level

100

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

166

species reactivity

rat, human, mouse

concentration

0.94mg/ml

technique(s)

western blot: 1:500-1:2000

UniProt accession no.

Q13224

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pTyr1070)

Gene Information

human ... GRIN2B(2904)

General description

This gene encodes a member of the N-methyl-D-aspartate (NMDA) receptor family within the ionotropic glutamate receptor superfamily. The encoded protein is a subunit of the NMDA receptor ion channel which acts as an agonist binding site for glutamate. The NMDA receptors mediate a slow calcium-permeable component of excitatory synaptic transmission in the central nervous system. The NMDA receptors are heterotetramers of seven genetically encoded, differentially expressed subunits including NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The early expression of this gene in development suggests a role in brain development, circuit formation, synaptic plasticity, and cellular migration and differentiation. Naturally occurring mutations within this gene are associated with neurodevelopmental disorders including autism spectrum disorder, attention deficit hyperactivity disorder, epilepsy, and schizophrenia.

Immunogen

A phospho synthetic peptide corresponding to residues surrounding Y1070 of human GRIN2B.

Physical form

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Storage and Stability

Store at -20℃. Avoid freeze / thaw cycles.

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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