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Merck
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SAB5700634

Anti-CDKN1B antibody produced in rabbit

Synonym(s):

CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1, p27 KIP 1

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
immunofluorescence
immunohistochemistry
western blot
Species reactivity:
mouse, human, rat
Citations:
Technique(s):
immunofluorescence: 1:20-1:50
immunohistochemistry: 1:50-1:200
western blot: 1:500-1:2000
Uniprot accession no.:
P46527

Key Documents

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

22

species reactivity

mouse, human, rat

concentration

0.61 mg/ml

technique(s)

immunofluorescence: 1:20-1:50
immunohistochemistry: 1:50-1:200
western blot: 1:500-1:2000

UniProt accession no.

P46527

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... CDKN1B(1027)

General description

This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4).

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-198 of human CDKN1B (NP_004055.1).

Physical form

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Preparation Note

Store at -20℃. Avoid freeze / thaw cycles.

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Regulatory Information

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