SAB5701107
Anti-Amyloid Precursor Protein (APP) Antibody
rabbit monoclonal
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.43
Clone:
monoclonal
Species reactivity:
human, rat, mouse
Application:
WB
Citations:
-
Product Name
Anti- APP antibody produced in rabbit,
biological source
rabbit
antibody product type
primary antibodies
clone
monoclonal
form
liquid
species reactivity
human, rat, mouse
concentration
0.93 mg/mL
technique(s)
western blot: 1:500-1:2000
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... APP(351)
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General description
This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2014]
Immunogen
A synthesized peptide derived from human APP
Physical form
Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
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Storage Class
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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