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Safety Information

SAB5701869

Sigma-Aldrich

Anti-Phospho-PKC alpha-T638 antibody produced in rabbit

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biological source

rabbit

Quality Level

100

antibody product type

primary antibodies

clone

monoclonal

form

liquid

species reactivity

human

concentration

0.29 mg/mL

technique(s)

western blot: 1:500-1:2000

UniProt accession no.

P17252

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pThr638)

Gene Information

human ... PRKCA(5578)

General description

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes. [provided by RefSeq, Jul 2008]

Immunogen

A phospho specific peptide corresponding to residues surrounding T638 of human Phospho-PKC alpha-T638

Physical form

Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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