SAB5701871
Anti-Phospho-PAK4/PAK5/PAK6-S474/S560/S602 antibody produced in rabbit
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About This Item
NACRES:
NA.41
UNSPSC Code:
12352203
Clone:
monoclonal
Species reactivity:
mouse, human
Application:
WB
Citations:
-
biological source
rabbit
Quality Segment
antibody product type
primary antibodies
clone
monoclonal
form
liquid
species reactivity
mouse, human
concentration
1.65 mg/mL
technique(s)
western blot: 1:500-1:2000
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
phosphorylation (pSer474/pSer560/pSer602)
General description
PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Immunogen
A phospho specific peptide corresponding to residues surrounding S474 of human PAK4
Physical form
Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
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Storage Class
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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