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SAB5702097

Sigma-Aldrich

Anti-Insulin Antibody, clone 4C3Y9, Rabbit Monoclonal

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Synonym(s):
IDDM,IDDM1,IDDM2,ILPR,IRDN,MODY10,INS,Insulin,insulin

biological source

rabbit

Quality Level

100

material

colorless

clone

4C3Y9, monoclonal

form

liquid

mol wt

12 kDa

species reactivity

mouse, rat

concentration

0.8 mg/mL

technique(s)

immunofluorescence: 1:50 - 1:200
immunohistochemistry: 1:50 - 1:200
western blot: 1:500 - 1:2000

color

colorless

isotype

IgG

immunogen sequence

MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAEDLQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSIC

UniProt accession no.

P01308

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... INS(3630)

General description

After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Insulin (P01308).
PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.

Application

WB, IHC, IF/ICC

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Regulatory Information

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