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Merck
CN

SAB5702242

Sigma-Aldrich

Anti-CD70 Antibody, clone 7F4S5, Rabbit Monoclonal

Synonym(s):

CD27L, CD27LG, TNFSF7

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.46

Key Documents

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biological source

rabbit

Quality Level

100

conjugate

unconjugated

material

colorless

clone

7F4S5, monoclonal

form

liquid

species reactivity

human

concentration

1 mg/mL

technique(s)

flow cytometry: 1:100 - 1:800
western blot: 1:500 - 1:2000

color

colorless

isotype

IgG

UniProt accession no.

P32970

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CD70(970)

General description

CD70 is a member of the TNF family whose expression is upregulated on DCs upon maturation. Its only receptor, CD27, is expressed on T cells and NK cells. The CD70/CD27 pathway promotes effector CD8+ T cells responses (by sustaining survival of CTLs) and influences polarization of CD4+ T cells, as it represents an alternative IL-12-independent pathway of Th1 priming and suppresses effector Th17 function.

Immunogen

PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Recombinant protein of human CD70.

Application

WB, FC

Pictograms

Exclamation markEnvironment
GHS07,GHS09

Signal Word

Warning

Hazard Statements

H317,H411

Hazard Classifications

Aquatic Chronic 2 - Skin Sens. 1

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Regulatory Information

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