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Merck
CN

SAB5702249

Anti-α-Synuclein (SNCA) Antibody

rabbit monoclonal, 10Y4X3

Synonym(s):

PD1,NACP,PARK1,PARK4,SNCA

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.46
Clone:
10Y4X3, monoclonal
Technique(s):
immunohistochemistry: 1:50 - 1:200, western blot: 1:500 - 1:1000
Application:
IHC, WB
Citations:
-

Key Documents

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Product Name

Anti-α-Synuclein Antibody, clone 10Y4X3, Rabbit Monoclonal,

biological source

rabbit

material

colorless

clone

10Y4X3, monoclonal

form

liquid

mol wt

18 kDa

concentration

1mg/mL

technique(s)

immunohistochemistry: 1:50 - 1:200, western blot: 1:500 - 1:1000

color

colorless

isotype

IgG

immunogen sequence

TKEQVTNVGGAVVTGVTAVAQKTVEGAGSIAAATGFVKKDQLGKNEEGAPQEGILEDMPVDPDNEAYEMPSEEGYQDYEPEA

UniProt accession no.

P37840

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Quality Level

100

Gene Information

human ... SNCA(6622)

species reactivity

human

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General description

Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer′s disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene.

Immunogen

PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Recombinant fusion protein containing a sequence corresponding to amino acids 59-140 of human alpha-Synuclein (NP_000336.1).

Application

WB, IHC

pictograms

Exclamation markEnvironment
GHS07,GHS09

signalword

Warning

hcodes

H317,H411

Hazard Classifications

Aquatic Chronic 2 - Skin Sens. 1

Storage Class

10 - Combustible liquids

wgk

WGK 3

Regulatory Information

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