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Merck
CN

SAB5702273

Anti-Ret Antibody, clone 3U8T6, Rabbit Monoclonal

Synonym(s):

RET,CDHF12,CDHR16,HSCR1,MEN2A,MEN2B,MTC1,PTC,RET-ELE1,RET51

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.46

Key Documents

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biological source

rabbit

Quality Level

100

conjugate

unconjugated

material

colorless

clone

3U8T6, monoclonal

form

liquid

species reactivity

human, rat, rat

concentration

1.00 mg/mL

technique(s)

immunofluorescence: 1:50 - 1:200
western blot: 1:500 - 1:1000

color

colorless

isotype

IgG

immunogen sequence

DISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFPRYPNDSVYANWM

UniProt accession no.

P07949

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... Ret(5979)

General description

This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed.

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 1000-1100 of human Ret (NP_066124.1).
PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.

Application

WB, IF/ICC

Pictograms

Exclamation markEnvironment
GHS07,GHS09

Signal Word

Warning

Hazard Statements

H317,H411

Hazard Classifications

Aquatic Chronic 2 - Skin Sens. 1

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Regulatory Information

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