SAB5702338
Anti-α-Actinin-4 Antibody, clone 5Y3R6, Rabbit Monoclonal
Synonym(s):
ACTININ-4, FSGS, FSGS1
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About This Item
NACRES:
NA.46
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
5Y3R6, monoclonal
Application:
immunofluorescence
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Species reactivity:
rat, human, rat
Citations:
Technique(s):
immunofluorescence: 1:50 - 1:200
immunoprecipitation (IP): 1:50 - 1:200
western blot: 1:500 - 1:2000
immunoprecipitation (IP): 1:50 - 1:200
western blot: 1:500 - 1:2000
Uniprot accession no.:
form
liquid
biological source
rabbit
conjugate
unconjugated
material
colorless
clone
5Y3R6, monoclonal
mol wt
100 kDa
species reactivity
rat, human, rat
concentration
0.55 mg/mL
technique(s)
immunofluorescence: 1:50 - 1:200
immunoprecipitation (IP): 1:50 - 1:200
western blot: 1:500 - 1:2000
color
colorless
isotype
IgG
immunogen sequence
MVDYHAANQSYQYGPSSAGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLEVISGERLPKPE
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... ACTN4(81)
Application
WB, IF/ICC, IP
General description
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis. [provided by RefSeq, Jul 2008]
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human α-Actinin-4 (O43707).
PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Storage Class
10 - Combustible liquids
wgk
WGK 1
Regulatory Information
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