SAB5702340
Anti-Thyroglobulin Antibody, clone 3I10H1, Rabbit Monoclonal
Synonym(s):
AITD3, TGN
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.46
biological source
rabbit
Quality Level
conjugate
unconjugated
material
colorless
clone
3I10H1, monoclonal
form
liquid
species reactivity
human, rat, rat
concentration
0.70 mg/mL
technique(s)
immunofluorescence: 1:50 - 1:200
immunohistochemistry: 1:50 - 1:200
color
colorless
isotype
IgG
immunogen sequence
STLSFYQRRRFSPDDSAGASALLRSGPYMPQCDAFGSWEPVQCHAGTGHCWCVDEKGGFIPGSLTARSLQIPQCPTTCEKSRTSGLLSSWKQARSQENPSP
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... TG(7038)
General description
Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. [provided by RefSeq, Nov 2009]
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1000-1100 of human Thyroglobulin (P01266).
PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Application
IHC, IF/ICC
Storage Class Code
10 - Combustible liquids
WGK
WGK 1
Regulatory Information
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