SAB5702416
Anti-MRE11 Antibody, clone 8Q2B3, Rabbit Monoclonal
Synonym(s):
ATLD, HNGS1, MRE11A, MRE11B
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About This Item
NACRES:
NA.46
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
8Q2B3, monoclonal
Application:
ChIP, WB
Citations:
-
biological source
rabbit
conjugate
unconjugated
material
colorless
clone
8Q2B3, monoclonal
form
liquid
mol wt
81 kDa
Quality Level
Gene Information
human ... MRE11(4361)
concentration
1.00 mg/mL
technique(s)
ChIP: 1:50 - 1:200, western blot: 1:500 - 1:2000
color
colorless
isotype
IgG
immunogen sequence
RHREQKEKTGEEINFGKLITKPSEGTTLRVEDLVKQYFQTAEKNVQLSLLTERGMGEAVQEFVDKEEKDAIEELVKYQLEKTQRFLKERHIDALEDKIDEE
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
General description
This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 400-500 of human MRE11 (P49959).
PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Application
WB,ChIP
Storage Class
10 - Combustible liquids
wgk
WGK 1
Regulatory Information
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